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  • Title: Necrotizing arteritis in acute poststreptococcal glomerulonephritis: report of a recovered case.
    Author: Ingelfinger JR, McCluskey RT, Schneeberger EE, Grupe WE.
    Journal: J Pediatr; 1977 Aug; 91(2):228-32. PubMed ID: 17662.
    Abstract:
    A patient with biopsy documented acute poststreptococcal glomerulonephritis and arteritis recovered completely with supportive therapy. Illness was preceded by group A streptococcal pharyngitis. At the time of presentation, serum creatinine concentration was 11.5 mg/dl. Serum cryoglobulins containing IgG and C3 were present. The first biopsy, performed during the acute illness, contained glomeruli with typical features of acute PSGN. Medium-sized arteries had extensive necrosis and leukocytic infiltration, and contained IgG, C3, and fibrin. Glomerular filtration rate returned to normal within three weeks; proteinuria cleared by three months, and microscopic hematuria by 11 months. Renal biopsy one year later showed minimal mesangial hypercellularity and no arteritis.
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