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  • Title: The gene for a halophilic glutamate dehydrogenase: sequence, transcription analysis and phylogenetic implications.
    Author: Benachenhou N, Baldacci G.
    Journal: Mol Gen Genet; 1991 Dec; 230(3):345-52. PubMed ID: 1766432.
    Abstract:
    We have isolated and sequenced the gene for a putative NADP-dependent glutamate dehydrogenase from the extremely halophilic archaebacterium Halobacterium salinarium. This gene is transcribed as a unique RNA molecule of about 1700 nucleotides. The 5' end of the transcript contains characteristic consensus transcription initiation and promoter sequences observed in halophilic archaebacteria. The encoded polypeptide, with a predicted length of 435 amino acids, shows significant overall homology and conservation of functional domains when compared with different eubacterial and eukaryotic glutamate dehydrogenases. Surprisingly, the archaebacterial protein shares a larger number of identical amino acid residues with homologous polypeptides from higher eukaryotes than with those from unicellular eukaryotes and eubacteria.
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