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Pubmed for Handhelds

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  • Title: Impact of empirical-therapy selection on outcomes of intravenous drug users with infective endocarditis caused by methicillin-susceptible Staphylococcus aureus.
    Author: Lodise TP, McKinnon PS, Levine DP, Rybak MJ.
    Journal: Antimicrob Agents Chemother; 2007 Oct; 51(10):3731-3. PubMed ID: 17664322.
    Abstract:
    This study compares beta-lactam and vancomycin among intravenous drug users with infective endocarditis caused by methicillin-susceptible Staphylococcus aureus. Patients who received vancomycin had higher infection-related mortality, even if they were switched to beta-lactam once culture results became available; this relationship persisted after logistic regression analysis controlling for clinical characteristics.
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