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  • Title: Gingival neurofibroma in a neurofibromatosis type 1 patient.
    Author: García de Marcos JA, Dean Ferrer A, Alamillos Granados F, Ruiz Masera JJ, García de Marcos MJ, Vidal Jiménez A, Valenzuela Salas B, García Lainez A.
    Journal: Med Oral Patol Oral Cir Bucal; 2007 Aug 01; 12(4):E287-91. PubMed ID: 17664914.
    Abstract:
    Neurofibroma is a benign peripheral nerve sheath tumour. It is one of the most frequent tumours of neural origin and its presence is one of the clinical criteria for the diagnosis of type 1 neurofibromatosis (NF-I). Neurofibromatosis type 1 is an autosomal dominantly inherited disease due to an alteration in the long arm of chromosome 17. About 50% of NF-I patients have no family history of the disease. NF-I patients have skin lesions (cafe au lait spots and neurofibromas) as well as bone malformations and central nervous system tumours. Diagnosis is based on a series of clinical criteria. Gingival neurofibroma in NF-I is uncommon. Treatment of neurofibromas is surgical resection. The aim of this paper is to report a case of NF-I with gingival involvement and to review the literature.
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