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  • Title: Biologically active indole alkaloids from Kopsia arborea.
    Author: Lim KH, Hiraku O, Komiyama K, Koyano T, Hayashi M, Kam TS.
    Journal: J Nat Prod; 2007 Aug; 70(8):1302-7. PubMed ID: 17665953.
    Abstract:
    Nine new indole alkaloids, rhazinoline (1), 19(S)-methoxytubotaiwine (2), 19(R)-methoxytubotaiwine (3), kopsamidine A (4), kopsamidine B (5), kopsinidine A (6), kopsinidine B (7), paucidactine C (8), and pericine N-oxide (9), in addition to several recently reported novel indoles and 34 other known ones, were obtained from the stem-bark extract of the Malayan Kopsia arborea. The structures were determined using NMR and MS analysis. Valparicine (12) showed pronounced cytotoxic effects against KB and Jurkat cells (IC(50) 13.0 and 0.91 microM, respectively).
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