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  • Title: Implications of diphenhydramine single-dose unintended ingestions in young children.
    Author: Stojanovski SD, Baker SD, Casavant MJ, Hayes JR, Robinson RF, Nahata MC.
    Journal: Pediatr Emerg Care; 2007 Jul; 23(7):465-8. PubMed ID: 17666928.
    Abstract:
    BACKGROUND: Diphenhydramine is frequently used in children, but the consequences of single unintended dose exposures in young children are unknown. METHODS: We evaluated 2000-2001 American Association of Poison Control Centers-Toxic Exposure Surveillance data on children exposed to diphenhydramine ingestions. RESULTS: Nine hundred twenty-six cases met the inclusion criteria; 49.1% were men, mean age was 29.7 +/- 13.0 months (range, 1-72 months). Approximately 85% of unintentional exposures occurred in 1- to 3-year-old children. The mean dose ingested was 6.4 +/- 6.1 mg/kg (median, 4.6 mg/kg). Thirty-two percent of patients were symptomatic: minor (29.4%), moderate (2.9%), and severe (0.11%). There was no relationship between dose and symptom severity. Diphenhydramine dose ingestion of 7.5 mg/kg or greater was not a predictor of severity (P = 0.47) CONCLUSIONS: The relationship between ingested dose and severity of symptoms was insignificant.
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