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  • Title: A case of sequential development of celiac disease and ulcerative colitis.
    Author: Dickey W.
    Journal: Nat Clin Pract Gastroenterol Hepatol; 2007 Aug; 4(8):463-7. PubMed ID: 17667995.
    Abstract:
    BACKGROUND: A 65-year-old white female who presented with flatulence and weight loss was investigated by celiac antibody testing, esophagogastroduodenoscopy, duodenal biopsy and colonoscopy. There were no positive findings, except for diverticulosis. Almost 5 years later repeat investigations performed in response to the patient's anemia confirmed the development of celiac disease. After 18 months of symptom improvement as a result of gluten exclusion the patient developed diarrhea, and colonoscopy revealed ulcerative colitis. INVESTIGATIONS: Physical examination; analysis of full blood count; measurement of serum ferritin, vitamin B(12), folate and C-reactive protein levels; thyroid and autoantibody profiling (including analysis of endomysial and tissue transglutaminase antibodies); CT scanning of the chest, abdomen and pelvis; and performance of esophagogastroduodenoscopy, push enteroscopy, colonoscopy and wireless capsule endoscopy. DIAGNOSIS: Celiac disease and ulcerative colitis. MANAGEMENT: Gluten-free diet, mesalazine and prednisolone.
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