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  • Title: [Toxic epidermal necrolysis induced by phenytoin and whole brain radiotherapy].
    Author: Fernández FA, Pintor E, Quesada R, Garcés FJ.
    Journal: Actas Dermosifiliogr; 2007 Sep; 98(7):483-5. PubMed ID: 17669303.
    Abstract:
    Toxic epidermal necrolysis (TEN) and Stevens-Johnson syndrome (SJS) have been associated with some drugs, particularly anticonvulsants such as phenytoin. Some authors have pointed out an increased risk of TEN/SJS when phenytoin is associated with whole brain radiotherapy. We report a patient diagnosed with breast adenocarcinoma and brain metastases that was on treatment with phenytoin and, shortly after receiving whole brain radiotherapy, developed toxic epidermal necrolysis.
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