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Title: [Influence of sex hormones on hemorrheology and plasma proteins during the menstrual cycle]. Author: Solerte SB, Fioravanti M, Magri F, Spinillo A, Guaschino S, Ferrari E. Journal: Rev Fr Gynecol Obstet; 1991 Feb 25; 86(2 Pt 2):139-42. PubMed ID: 1767163. Abstract: Our study was undertaken to verify the relation among sex hormone profile, hemorheologic pattern, blood lipids and plasma proteins throughout the menstrual cycle. In effect, the estrogenic activity has been related to blood hypercoagulability, thromboembolic disorders and to cardiovascular complications in normal women and in several diseases. The protocol study concerns 15 healthy young women (mean age 25 years), with normal body weight, investigated on day 7 (follicular phase), day 14 (ovulatory phase), and days 21, 25, 27 (mid-and late luteal phase) of menstrual cycle. We evaluated: blood, plasma and serum viscosity (at shear-rate of 450; 90; 4.5; 2.25 s-1), erythrocyte deformability, haematocrit, plasma fibrinogen and fibronectin, apolipoprotein A-A1-B, triglycerides, total-HDL and LDL-cholesterol, FSH, LH, 17-beta-estradiol, progesterone, testosterone, androstenedione, DHEA, DHEA-sulfate and the estradiol/progesterone ratio (E2/P ratio). Higher blood, serum and plasma viscosity (p less than 0.01), and lower erythrocyte deformability (p less than 0.01) were demonstrated during follicular and ovulatory phase, than in mid- and late luteal phases of menstrual cycle. Plasma fibrinogen (p less than 0.01) and fibronectin (p less than 0.001) were also significantly increased in ovulatory and follicular phases; whereas haematocrit, blood lipids and apolipoproteins remained unchanged throughout the menstrual cycle. Positive correlations among E2/P ratio, plasma viscosity, fibrinogen and fibronectin, and negative correlations between E2/P ratio and erythrocyte deformability, were found on day 21 (p less than 0.05) and day 25 (p less than 0.05).(ABSTRACT TRUNCATED AT 250 WORDS)[Abstract] [Full Text] [Related] [New Search]