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  • Title: [Venous insufficiency in the pregnant woman. Rheological correction by troxerutin].
    Author: Lefebvre G, Lacombe C.
    Journal: Rev Fr Gynecol Obstet; 1991 Feb 25; 86(2 Pt 2):206-8. PubMed ID: 1767175.
    Abstract:
    We realized a double-blind randomized study in 26 pregnant with clinical symptoms of lower limbs venous insufficiency. Both groups were similar and received either (n = 12) troxerutine (4 g/day) or placebo (n = 14), during 30 days. Evaluation at J0 and J30 was both clinical and rheological by mean of Myrenne aggregometer. After blood shear rate of 600 s-1, two parameters were determined: M after roughly stopping shear rate, M1 after diminishing to shear rate of 3 s-1. Results exhibited steady values in patients receiving troxerutine while a significant increasing values in patients receiving placebo for the two parameters M and M1. That result in erythrocyte antiaggregating action of troxerutine, hence lowering viscosity action, in venous insufficiency during pregnancy.
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