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  • Title: [Cardiac valvulopathy and dopamine agonist].
    Author: Grandas F.
    Journal: Neurologia; 2007 Dec; 22(10):870-81. PubMed ID: 17671852.
    Abstract:
    INTRODUCTION: To assess the possible relationship between treatment with dopamine agonists and cardiac fibrotic valvulopathy in Parkinson's disease, a systematic review of published articles describing this association was performed. METHOD: Cardiac valvulopathy has been described in parkinsonian patients taking pergolide, and in a few isolated cases treated with cabergoline or bromocriptine. RESULT: Until now, no cases of valvulopathy related to non-ergot dopamine agonists have been reported. CONCLUSIONS: Cumulative dose and duration of treatment are likely risk factors for development of valvulopathy. In some cases, the discontinuation of ergotic dopamine agonists was followed by improvement of valve regurgitation.
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