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  • Title: Peripheral blood and bone marrow TNF and TNF receptors in early and advanced stages of B-CLL in correlation with ZAP-70 protein and CD38 antigen.
    Author: Bojarska-Junak A, Hus I, Szczepanek EW, Dmoszyńska A, Roliński J.
    Journal: Leuk Res; 2008 Feb; 32(2):225-33. PubMed ID: 17675228.
    Abstract:
    The aim of the study was to evaluate TNF and TNF receptor levels in peripheral blood (PB) and bone marrow (BM) in correlation with clinical and laboratory parameters of B-CLL patients. TNF concentration was significantly higher in BM than in PB. In B-CLL patients elevated TNF and sTNF-RII plasma levels had a high correlation with adverse prognostic factors such as ZAP-70 and CD38. Moreover, the percentage of TNF-producing T cells was significantly higher in ZAP-70-positive comparing to ZAP-70-negative patients. TNF and sTNF-RII plasma levels were higher in the group of patients requiring treatment comparing to the patients who did not.
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