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  • Title: Nanoparticle-enhanced diffraction gratings for ultrasensitive surface plasmon biosensing.
    Author: Wark AW, Lee HJ, Qavi AJ, Corn RM.
    Journal: Anal Chem; 2007 Sep 01; 79(17):6697-701. PubMed ID: 17676761.
    Abstract:
    Ultrasensitive surface bioaffinity sensors are created by the adsorption of gold nanoparticles onto gold diffraction gratings. An enhanced diffraction obtained in a surface plasmon resonance geometry is observed due to the optical coupling of the planar surface plasmons in the grating to the localized surface plasmons in the gold nanoparticles. As a first example, these nanoparticle grating biosensors are employed to detect unmodified DNA at a concentration of 10 fM.
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