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  • Title: Rapid endometrial preparation for hysteroscopic surgery with oral desogestrel plus vaginal raloxifene: a prospective, randomized pilot study.
    Author: Cicinelli E, Pinto V, Tinelli R, Saliani N, De Leo V, Cianci A.
    Journal: Fertil Steril; 2007 Sep; 88(3):698-701. PubMed ID: 17678902.
    Abstract:
    OBJECTIVE: To evaluate the effects after 10 days of an original treatment combining oral progestins with vaginal raloxifene to maximize the antiproliferative effect on the endometrium. DESIGN: Prospective, randomized, clinical pilot study. SETTING: Academic research environment. PATIENT(S): Ninety women with endometrial polyps. INTERVENTION(S): On day 1 of the subsequent menstrual cycle, patients were randomized to receive oral desogestrel (n = 30) for 10 days combined with a tablet of raloxifene (60 mg) per vaginam (group A); oral desogestrel at 60 mg/day (n = 30; group B); or oral danazol at 200 mg, three times a day (n = 30; group C). MAIN OUTCOME MEASURE(S): Ultrasound measurement of endometrial thickness on day 11 of both the pretreatment and treatment cycles, surgeon satisfaction (0 to 10, visual analogue scale), and side effects. RESULT(S): At the second evaluation, the mean percentage reduction in endometrial thickness in group A was statistically significantly greater than in the other groups. Surgeon satisfaction in terms of endometrial thinning was also greater with group A. CONCLUSION(S): Oral desogestrel plus vaginal raloxifene provides a fast, low-cost, and satisfactory preparation of the endometrium for operative hysteroscopy.
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