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  • Title: [Rapid detection of chromosomes X and Y using dual-color primed in situ labeling technique].
    Author: Yang JB, Zhao ZY.
    Journal: Zhonghua Yi Xue Yi Chuan Xue Za Zhi; 2007 Aug; 24(4):477-8. PubMed ID: 17680549.
    Abstract:
    OBJECTIVE: To develop a rapid method for detection of chromosomes, and to present a feasible method for rapid detection of the interphase nuclei of uncultured amniocytes using modified dual-color primed in situ labeling (PRINS) technique. METHODS: Chromosomes X and Y were detected and analyzed by the modified dual-color PRINS in 205 amniotic fluid samples. RESULTS: The specific chromosomes were obtained on both metaphase and interphase nuclei. In more than 98% of the samples PRINS reactions with primers X and Y were successfully induced. One sample was properly identified and correctly scored as 47, XXY. CONCLUSION: The results suggest that PRINS technique is rapid, simple and cost-effective. It is also sensitive and specific, and thus useful for rapid detection of chromosome abnormalities.
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