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  • Title: Synthesis and bioactivities of 6,7,8-trimethoxy-N-aryl-4-aminoquinazoline derivatives.
    Author: Liu G, Hu DY, Jin LH, Song BA, Yang S, Liu PS, Bhadury PS, Ma Y, Luo H, Zhou X.
    Journal: Bioorg Med Chem; 2007 Oct 15; 15(20):6608-17. PubMed ID: 17681471.
    Abstract:
    A series of 4-aminoquinazoline derivatives is prepared by the nucleophilic substitution reaction of 6,7,8-trimethoxy-4-chloroquinazoline and aryl amine. The structures of the compounds are confirmed by elemental analysis, IR, and (1)H NMR spectral data. The compounds are also evaluated for their ability to inhibit tumor cells PC3, A431, Bcap-37, and BGC823 by MTT assays. Among them, 6b and 6e are found as potent inhibitors, with IC(50) values ranging from 5.8 to 9.8microM, in vitro assay.
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