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  • Title: [Synthesis, structure, and biological properties of some 8alpha-analogues of steroid estrogens with fluorine in position 2].
    Author: Belov VN, Dudkin VIu, Urusova EA, Starova GL, Selivanov SI, Nikolaev SV, Eshchenko ND, Morozkina SN, Shavva AG.
    Journal: Bioorg Khim; 2007; 33(3):315-23. PubMed ID: 17682387.
    Abstract:
    A total synthesis of 8alpha analogues of steroid estrogens with fluorine in position 2 was achieved. Structural features of these compounds were studied by the example of 17beta-acetoxy-2-fluoro-3-methoxy-8alpha-estra-1,3,5(10)-triene. It was shown that the 8alpha analogues of 2-fluorosubstituted steroid estrogens have a low uterotropic activity and retain the osteoprotective and hypocholesterolemic activities.
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