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  • Title: Synthesis and biological evaluation of cinnamyl compounds as potent antitumor agents.
    Author: Shin DS, Kim J, Han DC, Son KH, Lee CW, Kim HM, Hong SH, Kwon BM.
    Journal: Bioorg Med Chem Lett; 2007 Oct 01; 17(19):5423-7. PubMed ID: 17683933.
    Abstract:
    A series of cinnamyl compounds related to 2'-hydroxycinnamaldehyde were synthesized and their antitumor effects against human cancer cells evaluated. Hydroxylamine derivative 6 inhibited the growth of human cancer cells and human colon tumor xenograft in nude mice. Its antitumor effects belong to the induction of apoptosis and arresting cell cycle at G(2)/M phase, which is confirmed by detection of apoptosis markers and cell cycle analysis.
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