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  • Title: [Pharmacogenetics and anti-inflammatory effect of HMG-CoA reductase inhibitors].
    Author: Rosendo AB, Dal-Pizzol F, Fiegenbaum M, Almeida Sd.
    Journal: Arq Bras Endocrinol Metabol; 2007 Jun; 51(4):520-5. PubMed ID: 17684611.
    Abstract:
    Atherosclerosis is a result from the association of lipid deposition in the arterial wall and inflammatory process. This inflammatory process may be detected by clinical markers of systemic inflammation, such as ultrasensible C-reactive protein, which is associated with cardiovascular risk, independently of lipid levels. Statins reduce the inflammation associated to atherosclerosis, which may be verified by a reduction of the C-reactive protein levels. It seems that statins alter immune function by modulating post-translational protein prenylation. Individual genetic variations are associated with modulation of statins lipid-lowering effect; however, few studies have related the effect of the genetic variants with anti-inflammatory effect of statins. In addition to the genes involved in the cholesterol metabolism, genetic factors affecting statins pharmacodynamics and/or pharmacokinetics are potentially responsible for lipid and anti-inflammatory effects.
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