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  • Title: Enantioselective imidazole-directed allylation of aldimines and ketimines.
    Author: Perl NR, Leighton JL.
    Journal: Org Lett; 2007 Aug 30; 9(18):3699-701. PubMed ID: 17685538.
    Abstract:
    A new chiral allylchlorosilane has been developed that allows the highly enantioselective allylation and crotylation of a range of 2-imidazolylaldimines and ketimines. The method may be exploited for the protecting group-free synthesis of a diverse array of imidazole-bearing chiral carbinamines and, when coupled with ring-closing metathesis reactions, allows the one-pot synthesis of unusual heterocyclic motifs with potential relevance in medicinal chemistry.
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