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  • Title: [Relationship between tumor necrosis factor A-308 gene polymorphism and aggressive periodontitis].
    Author: Zhu XL, Meng HX, Xu L, Zhang L, Chen ZB, Shi D.
    Journal: Zhonghua Kou Qiang Yi Xue Za Zhi; 2007 May; 42(5):268-71. PubMed ID: 17686276.
    Abstract:
    OBJECTIVE: To investigate the relationship between tumor necrosis factor (TNF) A-308 gene polymorphism and aggressive periodontitis (AgP). METHODS: Anti-coagulated peripheral blood samples were obtained from 64 AgP patients, and 78 healthy controls (H). Genomic DNA was extracted from each sample. The TNF A-308 gene polymorphism was detected by standard polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) assay. Data were analyzed by SAS statistical software. RESULTS: There was no significant difference in distribution of TNF A-308 genotype between AgP patients and healthy controls. But the ORs for genotype GA and allele A were 22.2 and 16.1 respectively in non-smoking male AgP patients. CONCLUSIONS: The TNF A-308 genotype GA and allele A may be associated with AgP susceptibility in Chinese males.
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