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  • Title: [DNA methylation of human telomerase reverse transcriptase promoter region in human ameloblastoma].
    Author: Zhong M, Yan Y, Wang J, Liu J, Li L, Gong YB.
    Journal: Zhonghua Kou Qiang Yi Xue Za Zhi; 2007 May; 42(5):304-7. PubMed ID: 17686286.
    Abstract:
    OBJECTIVE: To study the DNA methylation of human telomerase reverse transcriptase (hTERT) promoter in ameloblastoma (AB) and investigate its clinical biological significance. METHODS: DNA methylation of hTERT promoter in 12 cases of AB and 11 cases of normal oral mucosa were detected by methylation-specific PCR. RESULTS: The positive cases of unmethylated hTERT promoter region in AB and normal oral mucosa were 4 (4/12) and 6 (6/11), respectively (P < 0.001). The positive cases of methylated hTERT promoter region in AB and normal oral mucosa were 11 (11/12) and 3 (3/11), respectively. Four cases of AB and 1 case of normal oral mucosa showed both DNA methylation and unmethylation of hTERT promoter region in the same time. CONCLUSIONS: DNA methylation of of hTERT promoter region in AB was more common than that in normal oral mucosa. The DNA methylation in hTERT promoter maybe regulate hTERT gene expression.
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