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  • Title: New nitrosoureas and their spin-labeled derivatives influence dopa-oxidase activity of tyrosinase.
    Author: Rachkova M, Raikova E, Raikov Z.
    Journal: Cancer Biochem Biophys; 1991 Jun; 12(1):59-64. PubMed ID: 1769006.
    Abstract:
    Tyrosinase is a key enzyme in melanine biosynthesis. The modulating effect of cytostatic agents on DOPA-oxidase activity of tyrosinase could be linked with the drug treatment of melanoma tumors. Two groups of nitrosoureas which influence DOPA-oxidase activity of tyrosinase were studied: new nitrosoureas and their spin-labeled derivatives synthesized in our laboratory. Using Burnett's spectrophotometric method (Burnett et al., 1967) the following effects were established: inhibition by CCNU, inhibition and the activating effects of the other investigated nitrosoureas depend on their physicochemical half-life. The predominant activating effect of the spin-labeled derivatives is due to the nitroxyl radical present in these compounds.
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