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  • Title: Synthesis of novel HIV protease inhibitors (PI) with activity against PI-resistant virus.
    Author: Raghavan S, Lu Z, Beeson T, Chapman KT, Schleif WA, Olsen DB, Stahlhut M, Rutkowski CA, Gabryelski L, Emini E, Tata JR.
    Journal: Bioorg Med Chem Lett; 2007 Oct 01; 17(19):5432-6. PubMed ID: 17692518.
    Abstract:
    A series of HIV protease inhibitors with modifications on the P3 position have been designed and synthesized. These compounds exhibit excellent antiviral activity against both the wild type enzyme and PI-resistant clinical viral isolates. The synthesis and biological activity of the compounds are described.
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