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  • Title: Contribution of the FtsQ transmembrane segment to localization to the cell division site.
    Author: Scheffers DJ, Robichon C, Haan GJ, den Blaauwen T, Koningstein G, van Bloois E, Beckwith J, Luirink J.
    Journal: J Bacteriol; 2007 Oct; 189(20):7273-80. PubMed ID: 17693520.
    Abstract:
    The Escherichia coli cell division protein FtsQ is a central component of the divisome. FtsQ is a bitopic membrane protein with a large C-terminal periplasmic domain. In this work we investigated the role of the transmembrane segment (TMS) that anchors FtsQ in the cytoplasmic membrane. A set of TMS mutants was made and analyzed for the ability to complement an ftsQ mutant. Study of the various steps involved in FtsQ biogenesis revealed that one mutant (L29/32R;V38P) failed to functionally insert into the membrane, whereas another mutant (L29/32R) was correctly assembled and interacted with FtsB and FtsL but failed to localize efficiently to the cell division site. Our results indicate that the FtsQ TMS plays a role in FtsQ localization to the division site.
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