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  • Title: Determination of lipophilicity and pKa measurement of some 4-imino-1,4-dihydrocinnoline-3-carboxylic acid and 4-oxo-1,4-dihydrocinnoline-3-carboxylic acid derivatives--isosteric analogues of quinolones.
    Author: Lewgowd W, Stańczaka A, Ochocki Z, Rzeszowska-Modzelewska K.
    Journal: Acta Pol Pharm; 2007; 64(3):195-200. PubMed ID: 17695140.
    Abstract:
    As a continuation of our study, physicochemical properties of some antibacterial active 4-imino-1,4-dihydrocinnoline-3-carboxylic acid and 4-oxo-1,4-dihydrocinnoline-3-carboxylic acid derivatives were investigated. Partition coefficient (log P), and dissociation constant (pKa) were experimentally determined and also calculated by the use of ACDLabs system software. The obtained values were correlated with experimental data.
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