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  • Title: Flatiron mice and ferroportin disease.
    Author: Johnson EE, Wessling-Resnick M.
    Journal: Nutr Rev; 2007 Jul; 65(7):341-5. PubMed ID: 17695375.
    Abstract:
    Flatiron mice provide the first genetic model that fully recapitulates the iron-loading disorder ferroportin disease. Unlike the other known genetic causes of hemochromatosis, missense mutations in the ferroportin gene are autosomal dominant. These new findings show that ferroportin disease results from dominant negative effects rather than haplo-insufficiency.
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