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  • Title: Distribution of insulin-like growth factors in condylar hyperplasia.
    Author: Götz W, Lehmann TS, Appel TR, Rath-Deschner B, Dettmeyer R, Luder HU, Reich RH, Jäger A.
    Journal: Ann Anat; 2007; 189(4):347-9. PubMed ID: 17695990.
    Abstract:
    Condylar hyperplasia (CH) is a local overgrowth of the condylar process of the temporomandibular joint (TMJ) of unknown etiology. Probably, growth factors like the insulin-like growth factors (IGFs) are involved in its pathogenesis. Specimens from 12 patients were investigated histologically and immunohistochemically to obtain the distribution of the IGFs-I and -II and the IGF1 receptor. The results revealed juvenile and adult subtypes. While generally IGF-II could only be detected weakly, in the juvenile cases strong immunostaining for IGF-I in cartilage and bone supposes an influence on pathological growth processes.
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