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  • Title: Copper-catalyzed amidation of sp3 C-H bonds adjacent to a nitrogen atom.
    Author: Zhang Y, Fu H, Jiang Y, Zhao Y.
    Journal: Org Lett; 2007 Sep 13; 9(19):3813-6. PubMed ID: 17696547.
    Abstract:
    We have developed a novel copper-catalyzed amidation of unactivated sp(3) C-H bonds adjacent to a nitrogen atom by using an inexpensive catalyst-oxidant (CuBr/(t)BuOOH) system under mild conditions. The dephenylation was first found for N-benzylaniline, and the new class of products provide diverse structures for pharmaceuticals and combinatorial chemistry.
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