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  • Title: Plasmid DNA and viral vector-based vaccines for the treatment of cancer.
    Author: Anderson RJ, Schneider J.
    Journal: Vaccine; 2007 Sep 27; 25 Suppl 2():B24-34. PubMed ID: 17698262.
    Abstract:
    Plasmid DNA and viral vector-based cancer vaccines have many inherent features that make them promising cancer vaccine candidates. This review focuses on the use of plasmid DNA and viral vector vaccines to deliver tumour-specific antigens to induce a tumour-specific immune response. Examples of different antigen delivery systems that have been tested in recent clinical trials are summarised and advantages and disadvantages of a number of delivery systems and approaches are discussed. Finally, an outlook on how plasmid DNA and viral vectors might be developed further as cancer vaccines is provided.
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