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  • Title: [Closed-loop titration of propofol guided by the bispectral index].
    Author: Liu N, Chazot T, Trillat B, Dumont GA, Fischler M.
    Journal: Ann Fr Anesth Reanim; 2007 Oct; 26(10):850-4. PubMed ID: 17698316.
    Abstract:
    This review analyzes the clinical studies concerning the automated perfusion, or closed-loop, of propofol guided by the bispectral index (BIS). To carry out the maintenance of general anaesthesia by a closed loop propofol-BIS is feasible as shown by studies comprising few low risk patients. We showed that induction of anaesthesia is feasible with a closed loop, haemodynamic stability being similar to a manual titration. A second study, bearing on the whole of the anaesthesia of patients ASA I to III undergoing very diverse surgical acts, showed that the closed loop propofol-BIS was more precise than a manual perfusion. This confirms that the closed loop propofol-BIS is not an esoteric research and that it represents a tool with a future for the clinician.
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