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  • Title: Cocaine disrupts pup-induced maternal behavior in juvenile and adult rats.
    Author: Johns JM, McMurray MS, Hofler VE, Jarrett TM, Middleton CL, Elliott DL, Mirza R, Haslup A, Elliott JC, Walker CH.
    Journal: Neurotoxicol Teratol; 2007; 29(6):634-41. PubMed ID: 17698321.
    Abstract:
    Impaired onset of maternal behavior in first generation rat dams was previously correlated with rearing by cocaine-treated dams and prenatal cocaine exposure. Pup-induced maternal behavior in non-lactating rats has not been examined with regard to cocaine exposure and rearing conditions. First generation male and female juveniles and young adult males reared by cocaine-treated or control dams and prenatally exposed to either cocaine or control conditions were tested for pup-induced maternal behavior at postnatal days 28 and 60. We now report disruptions in pup-induced maternal behavior in both 28 and 60 day old first generation offspring attributable to rearing condition and prenatal cocaine exposure.
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