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  • Title: Merkel cell carcinoma: more deaths but still no pathway to blame.
    Author: Lemos B, Nghiem P.
    Journal: J Invest Dermatol; 2007 Sep; 127(9):2100-3. PubMed ID: 17700621.
    Abstract:
    Merkel cell carcinoma (MCC) is a neuroendocrine skin cancer with a rising incidence (1500 U.S. cases per year) that now exceeds that of cutaneous T-cell lymphoma and a mortality (33%) exceeding that of melanoma. Despite this impact, little is known about its biology. Recent studies have shown that Ras/MAP kinase activity is absent and possibly detrimental to this cancer. This makes MCC distinct from other UV--induced skin cancers and highlights the question of what drives this malignancy.
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