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  • Title: Conjunctival nodules associated with Vogt-Koyanagi-Harada disease.
    Author: Nakao K, Shimonagano Y, Doi N, Sakamoto T.
    Journal: Graefes Arch Clin Exp Ophthalmol; 2007 Sep; 245(9):1383-6. PubMed ID: 17701198.
    Abstract:
    BACKGROUND: To report on conjunctival nodules as an unusual manifestation of Vogt-Koyanagi-Harada disease. METHODS: A 24-year-old woman presented with a two-month history of bilateral conjunctival injection and gradually decreased vision. Ophthalmological examinations revealed bilateral granulomatous uveitis and bulbar conjunctival nodules, and a biopsy of the conjunctival nodules was performed. RESULTS: The biopsy specimens showed noncaseating granulomas. The major components of the infiltrating lymphocytes were CD8-positive T cells. Topical corticosteroid therapy reduced the anterior segment inflammation, and the conjunctival nodules disappeared within a week. Afterwards, the patient demonstrated bilateral retinal detachments, sunset glow fundus and alopecia, and, therefore, was diagnosed to have Vogt-Koyanagi-Harada disease four months after the first symptoms. CONCLUSIONS: Conjunctival nodules may represent the primary manifestation of Vogt-Koyanagi-Harada disease.
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