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  • Title: Determination of bevantolol in human plasma by high performance liquid chromatography using solid phase extraction technique.
    Author: Trung TQ, Long PH, Al-Abd AM, Ku HJ, Lee HY, Hwang SJ, Kim KH.
    Journal: Arch Pharm Res; 2007 Jul; 30(7):890-7. PubMed ID: 17703743.
    Abstract:
    A method was developed and fully validated for the determination of bevantolol, an adrenergic-receptor blocker, in human plasma. Bevantolol and betaxolol as internal standard (I.S) were extracted from 1 mL of human plasma by solid phase extraction technique using Sep-pak silica cartridge. Chromatographic separation was accomplished under isocratic conditions using a reverse-phase C8 analytical column and mixture of dibasic ammonium phosphate (pH 5.7; 50 mM)-acetonitrile (75:25, v/v) as mobile phase, with a detection wavelength at 220 nm. The method was proved to be specific by testing six different human plasma sources. Linearity was established for the concentration ranges of 40-1600 ng/mL with correlation coefficent of 0.9995. The lower limit of quantification 40 ng/mL with precision of 10.9% as C.V%.
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