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  • Title: [Synthesis of derivatives of (9S) -9-hydroxyl-12-methylene erythromycin A and their antibacterial activity in vitro].
    Author: Xu P, Yang Y, Shi Y, Lei PS, Liu L.
    Journal: Yao Xue Xue Bao; 2007 May; 42(5):497-501. PubMed ID: 17703771.
    Abstract:
    The derivatives of (9S)-9-hydroxyl-12-methylene erythromycin A were synthesized by using erythromycin A as a starting material. An intermediate (9S)-9,11-O-isopropylidene-6-O-allyl-2' ,4"-O-bis(benzoyl)-12,21-anhydro erythromycin A 12 was obtained. The antibacterial activity in vitro of two compounds, 6 and 11, was tested. The preliminary biological test showed that two compounds exhibited less potent antibacterial activity in vitro.
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