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  • Title: Heterogeneity of immunopathological features of AChR/MuSK autoantibody-negative myasthenia gravis.
    Author: Hayashi A, Shiono H, Ohta M, Ohta K, Okumura M, Sawa Y.
    Journal: J Neuroimmunol; 2007 Sep; 189(1-2):163-8. PubMed ID: 17706794.
    Abstract:
    We compared B cells and germinal centers in thymus from myasthenia gravis (MG) patients either with anti-acetylcholine receptor (AChR) autoantibodies or with neither anti-muscle-specific tyrosine kinase (MuSK) nor anti-AChR (seronegative MG: SN-MG). The numbers and frequencies of total and germinal center B cells varied in the SN-MG thymi, some of which were normal/atrophic. Others were clearly hyperplastic, their B cell parameters overlapping with those in AChR-positive MG, which implicates the thymus in pathogenesis. Indeed, some SN-MG patients apparently benefited from thymectomy, which should be considered a management option.
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