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  • Title: Is the blood-brain barrier relevant in metastatic germ cell tumor?
    Author: Azar JM, Schneider BP, Einhorn LH.
    Journal: Int J Radiat Oncol Biol Phys; 2007 Sep 01; 69(1):163-6. PubMed ID: 17707269.
    Abstract:
    PURPOSE: Germ cell tumors are uniquely chemosensitive and curable, even with advanced metastatic disease. Central nervous system recurrence can terminate a complete remission in other chemosensitive tumors, such as small cell lung cancer, because of the blood-brain barrier (BBB). We propose to document that the BBB is also relevant in germ cell tumors despite their dramatic chemosensitivity. METHODS AND MATERIALS: We present five cases illustrating the concept of the BBB in patients with metastatic testicular cancer treated with chemotherapy. RESULTS: In our large series of patients with metastatic testicular cancer treated with chemotherapy, we identified 5 unique patients. These patients were rendered free of disease only to experience relapse in the brain alone. This included 1 patient who initially had good-risk metastatic disease by means of the International Germ Cell Collaborative Group staging system at the onset of chemotherapy. CONCLUSIONS: The BBB is relevant in patients with metastatic testicular cancer.
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