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  • Title: tRNA import into yeast mitochondria is regulated by the ubiquitin-proteasome system.
    Author: Brandina I, Smirnov A, Kolesnikova O, Entelis N, Krasheninnikov IA, Martin RP, Tarassov I.
    Journal: FEBS Lett; 2007 Sep 04; 581(22):4248-54. PubMed ID: 17707817.
    Abstract:
    In Saccharomyces cerevisiae, one of two cytosolic lysine-tRNAs is partially imported into mitochondria. We demonstrate that three components of the ubiquitin/26S proteasome system (UPS), Rpn13p, Rpn8p and Doa1p interact with the imported tRNA and with the essential factor of its mitochondrial targeting, pre-Msk1p. Genetic and biochemical assays demonstrate that UPS plays a dual regulatory role, since the overall inhibition of cellular proteasome activity reduces tRNA import, while specific depletion of Rpn13p or Doa1p increases it. This result suggests a functional link between UPS and tRNA mitochondrial import in yeast and indicates on the existence of negative and positive import regulators.
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