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  • Title: Effects of methylphenidate on working memory components: influence of measurement.
    Author: Bedard AC, Jain U, Johnson SH, Tannock R.
    Journal: J Child Psychol Psychiatry; 2007 Sep; 48(9):872-80. PubMed ID: 17714372.
    Abstract:
    BACKGROUND: To investigate the effects of methylphenidate (MPH) on components of working memory (WM) in attention-deficit hyperactivity disorder (ADHD) and determine the responsiveness of WM measures to MPH. METHODS: Participants were a clinical sample of 50 children and adolescents with ADHD, aged 6 to 16 years old, who participated in an acute randomized, double-blind, placebo-controlled, crossover trial with single challenges of three MPH doses. Four components of WM were investigated, which varied in processing demands (storage versus manipulation of information) and modality (auditory-verbal; visual-spatial), each of which was indexed by a minimum of two separate measures. RESULTS: MPH improved the ability to store visual-spatial information irrespective of instrument used, but had no effects on the storage of auditory-verbal information. By contrast, MPH enhanced the ability to manipulate both auditory-verbal and visual-spatial information, although effects were instrument specific in both cases. CONCLUSIONS: MPH effects on WM are selective: they vary as a function of WM component and measurement.
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