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  • Title: First enantioselective organocatalytic conjugate addition of aldehydes to vinyl phosphonates.
    Author: Sulzer-Mossé S, Tissot M, Alexakis A.
    Journal: Org Lett; 2007 Sep 13; 9(19):3749-52. PubMed ID: 17715930.
    Abstract:
    Chiral amines catalyze the enantioselective conjugate addition of aldehydes to vinyl phosphonates in high yields and with enantioselectivities up to 97% ee. This novel process provides synthetically useful chiral gamma-geminal phosphonate aldehydes which can be easily converted in a few steps into chiral beta-substituted vinyl phosphonates with conservation of the optical purity.
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