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  • Title: Melkersson-Rosenthal syndrome: a form of pseudoangioedema.
    Author: Kakimoto C, Sparks C, White AA.
    Journal: Ann Allergy Asthma Immunol; 2007 Aug; 99(2):185-9. PubMed ID: 17718107.
    Abstract:
    BACKGROUND: Melkersson-Rosenthal syndrome is an unusual cause of facial swelling that can be confused with angioedema. OBJECTIVE: To describe a young woman with facial swelling initially considered to be angioedema. METHODS: A biopsy specimen of the eyelid demonstrated findings consistent with Melkersson-Rosenthal syndrome. RESULTS: After reviewing the differential diagnosis of pseudoangioedema, a presumptive diagnosis of Melkersson-Rosenthal syndrome was made. The patient was successfully treated with infliximab for Melkersson-Rosenthal syndrome. Owing to medication adverse effects, infliximab treatment was discontinued. Treatment was then continued with adalimumab, with good effect and without adverse events. CONCLUSIONS: We report the case of a patient with Melkersson-Rosenthal syndrome presenting as angioedema. Furthermore, we report the first successful treatment of Melkersson-Rosenthal syndrome with adalimumab.
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