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  • Title: Characterization and immunogenicity of meningococcal group C conjugate vaccine prepared using hydrazide-activated tetanus toxoid.
    Author: Silveira IA, Bastos RC, Neto MS, Laranjeira AP, Assis EF, Fernandes SA, Leal ML, Silva WC, Lee CH, Frasch CE, Peralta JM, Jessouroun E.
    Journal: Vaccine; 2007 Oct 10; 25(41):7261-70. PubMed ID: 17719147.
    Abstract:
    The steps to produce, purify and control an immunogenic Brazilian conjugate vaccine against group C meningococcus (MenCPS-TT) using hydrazide-activated tetanus toxoid were developed. The conjugation methodology reduced the reaction time easily allowing scale-up. One freeze-dried pilot vaccine lot purified by tangential filtration, showed satisfactory quality control results including safety and stability. The pilot vaccine was immunogenic in mice in a dose-dependent fashion generating a 10-20-fold rise in IgG response in mice. The vaccine also induced high bactericidal titers. Vaccine concentrations of 1 and 0.1 microg showed higher avidity indices, suggesting induction of immunologic memory. These results support initiation of Phase I clinical studies with the MenCPS-TT conjugate vaccine.
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