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  • Title: Vasopressin-neurophysin and DST in major depression: relationship with suicidal behavior.
    Author: Pitchot W, Scantamburlo G, Pinto E, Hansenne M, Reggers J, Ansseau M, Legros JJ.
    Journal: J Psychiatr Res; 2008 Jul; 42(8):684-8. PubMed ID: 17720191.
    Abstract:
    The purpose of the present study was to assess if AVP-neurophysin is associated with hypercortisolemia and suicidal behaviour in depressed patients. The study included 28 patients subgrouped into suicide attempters (n=13) and nonattempters (n=15). We assessed basal AVP-neurophysins concentrations and post-dexamethasone (DST) cortisol levels. Concentrations of AVP-neurophysins did not differ between DST suppressors and nonsuppressors: 0.29+/-0.13 ng/ml vs 0.36+/-0.21 ng/ml, (F=1.1, df=1, 27, p=0.30). Suicide attempters did not differ from nonattempters for AVP-neurophysins levels. Our results fail to support a role of AVP in the early cortisol escape.
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