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  • Title: Straight deep hypothermic arrest: experience in 394 patients supports its effectiveness as a sole means of brain preservation.
    Author: Gega A, Rizzo JA, Johnson MH, Tranquilli M, Farkas EA, Elefteriades JA.
    Journal: Ann Thorac Surg; 2007 Sep; 84(3):759-66; discussion 766-7. PubMed ID: 17720372.
    Abstract:
    BACKGROUND: The three methods of brain preservation for aortic arch surgery--straight deep hypothermic circulatory arrest (DHCA) without perfusion adjuncts, retrograde cerebral perfusion, and antegrade cerebral perfusion--remain controversial. Patients in this report underwent surgery solely with DHCA. METHODS: Straight DHCA at 19 degrees C was used in 394 patients (267 males, 127 females) during a 10-year period. Mean age was 61.3 years (range, 15 to 88 years). Eighty-seven cases (22.1%) were urgent or emergencies. Thirty-eight (9.6%) were performed for descending or thoracoabdominal pathology and the rest for ascending/arch (102 hemiarch, 49 total arch). Ninety-one patients (23.1%) had dissections. The head was packed in ice. No barbiturate coma was used. RESULTS: DHCA lasted a mean of 31.0 minutes (range, 10 to 66 minutes). Reexploration for bleeding was required in 4.5% (18/394). Overall mortality was 6.3% (25/394). Mortality was 3.6% (11/307) for elective cases and 16% (14/87) for emergency cases. The stroke rate was 4.8% (19/394). The seizure rate was 3.1% (12/394). Forty-five patients with high professional cognitive demands (MD, PhD, attorney, etc) performed without detriment postoperatively. Among patients with DHCA exceeding 40 minutes, the stroke rate was 13.1% (8/61); a neuroradiologist's review of brain computed tomography scans found 62.5% of these strokes (5/8) to be embolic and 37.5% (3/8) hypoperfusion related. By multivariable logistic regression, emergency operation and descending location increased morbidity and mortality. CONCLUSIONS: Straight DHCA without adjunctive perfusion suffices as a sole means of cerebral protection. Stroke and seizure rates are low. Cognitive function, by clinical assessment, is excellent. Especially for straightforward ascending/arch reconstructions, there is little need for the added complexity of brain perfusion strategies.
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