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  • Title: Peptidomimetics via copper-catalyzed azide-alkyne cycloadditions.
    Author: Angell YL, Burgess K.
    Journal: Chem Soc Rev; 2007 Oct; 36(10):1674-89. PubMed ID: 17721589.
    Abstract:
    This critical review concerns the impact of copper-mediated alkyne-azide cycloadditions on peptidomimetic studies. It discusses how this reaction has been used to insert triazoles into peptide chains, to link peptides to other functionalities (e.g. carbohydrates, polymers, and labels), and as a basis for evolution of less peptidic compounds as pharmaceutical leads. It will be of interest to those studying this click reaction, peptidomimetic secondary structure and function, and to medicinal chemists.
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