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  • Title: Novel indanyl-substituted imidazo[1,2-a]pyridines as potent reversible inhibitors of the gastric H+/K+-ATPase.
    Author: Zimmermann PJ, Buhr W, Brehm C, Palmer AM, Feth MP, Senn-Bilfinger J, Simon WA.
    Journal: Bioorg Med Chem Lett; 2007 Oct 01; 17(19):5374-8. PubMed ID: 17723299.
    Abstract:
    A series of novel 8-indanylamino- and 8-indanyloxy-substituted imidazo[1,2-a]pyridines with reduced lipophilicity was synthesized from easily accessible starting compounds. The anti-secretory activity of these compounds has been assessed in a competitive binding assay against H(+)/K(+)-ATPase from hog gastric mucosa. Some of the compounds proved to be potent inhibitors of the gastric acid pump.
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