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  • Title: 1,2,4-benzothiadiazine linked pyrrolo[2,1-c][1,4]benzodiazepine conjugates: synthesis, DNA-binding affinity and cytotoxicity.
    Author: Kamal A, Khan MN, Reddy KS, Ahmed SK, Kumar MS, Juvekar A, Sen S, Zingde S.
    Journal: Bioorg Med Chem Lett; 2007 Oct 01; 17(19):5345-8. PubMed ID: 17723301.
    Abstract:
    Benzothiadiazine-pyrrolobenzodiazepine conjugates linked through different alkane spacers have been prepared. These new classes of hybrid molecules exhibit cytotoxicity against many cancer cell lines. Their DNA thermal denaturation studies have been carried out and one of the compounds (4b) elevates the DNA helix melting temperature of the CT-DNA by 6.7 degrees C after incubation for 36 h.
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