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  • Title: Use of Glubran 2 acrylic glue in interventional neuroradiology.
    Author: Raffi L, Simonetti L, Cenni P, Leonardi M.
    Journal: Neuroradiology; 2007 Oct; 49(10):829-36. PubMed ID: 17724584.
    Abstract:
    INTRODUCTION: Glubran 2 is a cyanoacrylate-based synthetic glue modified by the addition of a monomer synthesized by the manufacturer. With this material it is possible to obtain the stability of endovascular embolization that is needed to treat tumours and vascular disease. MATERIAL AND METHODS: We report our 3-year experience of the use of Glubran for treating extracerebral tumours, spinal tumours, spinal arteriovenous malformations, and brain and spine dural fistulae. Glubran 2 was diluted with Lipiodol and injected in a continuous column with the flow rate monitored by seriography. The injection was stopped when retrograde flow was displayed in the afferent vessel. RESULTS: There were no periprocedural or subsequent clinical complications and the glue resulted in successful selective permanent occlusion with intralesional penetration similar to the angiographic features of microcatheterization. CONCLUSIONS: The embolization procedure was technically straightforward and relatively safe. However, Glubran 2 can be difficult to use and the procedure does carry major risks for patients. Glue injection requires in-depth study of the lesion, its circulation and the collateral circulation to avoid severe complications due to inappropriate use.
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