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  • Title: Measurements of the effect of dipyridamole on regional myocardial blood flow with positron emission tomography and the first-pass flow model.
    Author: Himi T, Endo M, Yoshida K, Kagaya A, Masuda Y, Inagaki Y, Fukuda H, Iinuma T, Yamasaki T, Fukuda N.
    Journal: Am J Physiol Imaging; 1991; 6(3):110-5. PubMed ID: 1772691.
    Abstract:
    We assessed percent changes of regional myocardial blood flow (RMBF) after infusion of dipyridamole (0.56 mg/kg) with dynamic N-13 ammonia PET and the first-pass flow model. Positron emission tomography (PET) was performed at rest and after infusion of dipyridamole in 17 participants [five normal subjects, five patients with hypertrophic cardiomyopathy (HCM), and seven patients with coronary artery disease]. Dipyridamole increased RMBF 126 +/- 69% (mean +/- SD) in normal subjects and 55 +/- 43% in the patients with HCM. In the cases of coronary artery disease, the percent changes of RMBF were +19 +/- 19% in ischemic areas and +76 +/- 23% in nonischemic areas. These results demonstrate that N-13 ammonia dynamic PET study is useful in assessing the percent changes of RMBF induced by dipyridamole infusion.
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